Zoladex and Flutamide Versus Bilateral Orchiectomy
نویسندگان
چکیده
منابع مشابه
Bilateral orchiectomy with or without flutamide for metastatic prostate cancer.
BACKGROUND Combined androgen blockade for the treatment of metastatic prostate cancer consists of an antiandrogen drug plus castration. In a previous trial, we found that adding the antiandrogen flutamide to leuprolide acetate (a synthetic gonadotropin-releasing hormone that results in medical ablation of testicular function) significantly improved survival as compared with that achieved with p...
متن کاملBilateral orchiectomy versus total androgen blockade in the management of metastatic cancer prostate
Among all cancers that arise in the prostate the most common is adenocarcinoma accounting for more than 95%. The etiology of prostate cancer remains unknown and no definite carcinogen is known to be responsible; a viral etiology has been suggested but not verified. It is possible that alternation in estrogen & androgen balance and metabolic alteration in prostate may play a role but exact clini...
متن کاملAndrogen deprivation therapy through bilateral orchiectomy: increased metabolic risks.
Prostate cancer is one of the most common malignancies in men. Previous research has determined that androgen deprivation therapy (ADT) may be accompanied by an unfavourable metabolic profile. In this prospective study, 133 men were recruited, including 46 prostate cancer patients who had undergone bilateral orchiectomy and been on flutamide (the ADT group), 37 men with prostate cancer who had ...
متن کاملComparison of finasteride versus flutamide in the treatment of hirsutism.
OBJECTIVE To compare the effectiveness of finasteride and flutamide in the treatment of hirsutism in patients with polycystic ovary syndrome (PCOS) and with idiopathic hirsutism. DESIGN Randomized study. PATIENTS One hundred and ten hirsute patients were selected: 64 women with PCOS and 46 with idiopathic hirsutism. METHODS Patients were assigned randomly to receive 5mg finasteride once d...
متن کاملPsychosocial implications and the duality of life outcomes for patients with prostate carcinoma after bilateral orchiectomy.
OBJECTIVES The study presented focuses on patients' psychosocial status after a prostate cancer diagnosis that underwent a bilateral orchiectomy. METHODS We evaluated the psychosocial implications of 89 patients with prostate cancer after performing castration and a bilateral orchiectomy. RESULTS Patients suffered significantly more from sleep disorders during hospitalisation when compared ...
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ژورنال
عنوان ژورنال: Cancer
سال: 1990
ISSN: 0008-543X
DOI: 10.1002/cncr.1990.66.s5.1045